Application of Rotatable Central Composite Design in the Preparation and Optimization of Poly (Lactic-co-Glycolic Acid) Nanoparticles for Controlled Delivery of HSA
نویسندگان
چکیده
منابع مشابه
Application of rotatable central composite design in the preparation and optimization of poly(lactic-co-glycolic acid) nanoparticles for controlled delivery of paclitaxel.
CONTEXT Polymeric carrier systems of paclitaxel (PCT) offer advantages over only available formulation Taxol® in terms of enhancing therapeutic efficacy and eliminating adverse effects. OBJECTIVE The objective of the present study was to prepare poly (lactic-co-glycolic acid) nanoparticles containing PCT using emulsion solvent evaporation technique. METHODS Critical factors involved in the ...
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However, problems such as osteoporosis due to high elasticity of metals relative to bones, and local infections and systemic problems caused by releasing metallic ions have motivated research on replacing metallic screws with non metallic ones. In this study, the composite containing poly-l-lactic acid and bioactive glass fibers were considered for the design of the screw using ABAQUS software ...
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A novel rhein formulation based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) suitable for oral administration was developed in this study. The designed nanosystems were obtained by a modified spontaneous emulsification solvent diffusion method. The morphology of rhein-loaded PLGA NPs showed a spherical shape with a smooth surface, without any particle aggregation. Mean size of th...
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Poly(lactic-co-glycolic) acid (PLGA) has attracted a considerable amount of interest for biomedical application due to its biocompatibility, tailored biodegradation rate (depending on the molecular weight and copolymer ratio), approval for clinical use in humans by the U.S. Food and Drug Administration (FDA), the potential to change surface properties to create better interaction with biologica...
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ژورنال
عنوان ژورنال: Nano Biomedicine and Engineering
سال: 2011
ISSN: 2150-5578
DOI: 10.5101/nbe.v3i1.p34-41